| 发明名称 |
CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
| 摘要 |
The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure:;;wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same. |
| 申请公布号 |
US2016339024(A1) |
申请公布日期 |
2016.11.24 |
| 申请号 |
US201615130266 |
申请日期 |
2016.04.15 |
| 申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Nti-Addae Kwame Wiredu;O'Neil Simon Adam;Zhang Yuegang;Waldo Michael;Mudunuri Praveen;Song Bin;Van Alsten John Gregg;Strohmeier Mark;Stavropoulos Kathy;Kadiyala Irina Nikolaevna;Navamal Mettachit |
| 分类号 |
A61K31/506;C07D401/14;C07B59/00;C07C55/14;C07C55/10;C07C57/145;C07C57/15;C07C59/265;C07C63/08;A61K31/337;A61K31/555;A61K31/517;A61K31/7048;A61K31/704;A61K38/14;A61K31/5025;A61K33/24;A61K31/513;A61K39/395;C07K16/28;A61K45/06 |
主分类号 |
A61K31/506 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A co-crystal comprising a compound of the formulaanda co-crystal former, wherein the co-crystal former is adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid, wherein each of R1 and R2 is hydrogen or deuterium. |
| 地址 |
Boston MA US |
