发明名称 |
Selective thrombin inhibitors |
摘要 |
The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: in which R1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group, X represents a group of formula R2 and R3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, or R2 and R3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl, R4 represents hydrogen, lower alkyl or lower alkoxy, R5 represents alkanesulfonyl; alkoxycarbonyl; alkylcarbonyl; formyl; lower alkyl; aryl substituted or unsubstituted with alkoxy or haloalkyl; or hydroxy-substituted lower alkyl, and R6 and R7 independently of one another represent hydrogen, lower alkyl or amino, and to a process for preparation thereof and a pharmaceutical composition for thrombin inhibition which comprises the compound of formula (I) as an active ingredient.
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申请公布号 |
US5985899(A) |
申请公布日期 |
1999.11.16 |
申请号 |
US19970967661 |
申请日期 |
1997.11.10 |
申请人 |
LG CHEMICAL LTD. |
发明人 |
OH, YEONG SOO;KIM, SANG SOO;HWANG, SANG YEUL;YUN, MI KYUNG;HWANG, SEONG RYUL;HONG, SEONG WON;LEE, YONG HEE;JEONG, YI NA;LEE, KOO;SHIN, YOU SEUNG |
分类号 |
C07C257/22;C07C311/19;C07C311/29;C07C311/42;C07D211/60;C07D295/185;C07D295/205;C07D295/26;(IPC1-7):A61K31/445;C07D211/34 |
主分类号 |
C07C257/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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