DENDRITIC CELL BASED VACCINES

摘要

The present invention provides an isolated human dendritic cell comprising a recombinant alphavirus vector RNA that comprises a heterologous nucleic acid sequence encoding an antigen. In particular embodiments, the alphavirus vector RNA is a Venezuelan Equine Encephalitis virus (VEE) vector RNA. In other embodiments, the antigen is an infectious disease antigen or a cancer antigen. Also provided are compositions and pharmaceutical formulations comprising the inventive dendritic cells, as well as methods of inducing an immune response against an infectious agent or a cancer and methods of treating an infectious disease or cancer.