Racemic Drug Resolution Using Polymer Supported Chiral Selector

摘要

The present invention relates to a process for the separation of enantiomers or resolution of racemic mixtures using high surface area core-shell polymer beads. The present invention further relates to a core-shell functionalized polymer comprising a core which comprises copolymer made from monomers selected from non-aromatic acrylate, ethylene dimethacrylate and divinyl-benzene, a shell which comprises monomers selected from glycidyl ethers of methacrylate and a chiral selector selected from tartaric acid derivatives and amino acids.

主权项

1. A core-shell functionalized polymer comprising:
i. a core comprising a crosslinked copolymer made from monomers, said monomers selected from non-aromatic acrylate, ethylene dimethacrylate and divinylbenzene and; ii. a shell, comprising a polymer made from monomers selected from glycidyl ethers of methacrylate; and iii. a chiral selector selected from tartaric acid derivatives and amino acids.