| 主权项 |
1. A topical composition comprising, in a topically acceptable vehicle, an effective amount of a compound having the structure of formula (I): wherein, RN are independently selected at each occurrence from hydrogen or C1-C12 hydrocarbons, optionally containing from 1-8 heteroatoms selected from halogen, O, N, and S and combinations thereof; and wherein two groups RN on the same nitrogen atom may together form a three- to six-membered ring; Ra is independently selected from hydrogen, —F; —Cl; —Br; —I; —OH, —OR*; —NH2; —NHR*; —N(R*)2; —N(R*)3+; —N(R*)—OH; —N(→O)(R*)2; —O—N(R*)2; —N(R*)—O—R*; —N(R*)—N(R*)2; —C═N—R*; —N═C(R*)2; —C═N—N(R*)2; —C(═NR*)—N(R*)2; —SH; —SR*; —CN; —NC; —(C═O)—R*; —CHO; —CO2H; —CO2−; —CO2R*; —(C═O)—S—R*; —O—(C═O)—H; —O—(C═O)—R*; —S—(C═O)—R*; —(C═O)—NH2; —(C═O)—N(R*)2; —(C═O)—NHNH2; —O—(C═O)—NHNH2; —(C═S)—NH2; —(C═S)—N(R*)2; —N(R*)—CHO; —N(R*)—(C═O)—R*; —(C═NR)—O—R*; —O—(C═NR*)—R*, —SCN; —NCS; —NSO; —SSR*; —N(R*)—C(═O)—N(R*)2; —N(R*)—C(═S)—N(R*)2; —SO2—R*; —O—S(═O)2—R*; —S(═O)2—OR*; —N(R*)—SO2—R*; —SO2—N(R*)2; —O—SO3; —O—S(═O)2—OR*; —O—S(═O)—OR*; —O—S(═O)—R*; —S(═O)—OR*; —S(═O)—R*; —NO; —NO2; —NO3; —O—NO; —O—NO2; —N3; —N2—R*; —N(C2H4); —Si(R*)3; —CF3; —O—CF3; —PR*2; —O—P(═O)(OR*)2; —P(═O)(OR*)2; C1-C8 perfluoroalkyl; an aliphatic C1-C8 hydrocarbon radical; a C1-C8 aromatic hydrocarbon radical; or a C1-C8 heteroaryl radical; X1 and X2 are independently selected from oxygen, sulfur, NRN, or CR*R*; R* is independently at each occurrence hydrogen or a straight chained, branched, or cyclic C1-C20 hydrocarbon radical, optionally substituted with one or more groups Ra or with 1-6 heteroatoms selected from nitrogen, oxygen, sulfur, or halogen and combinations thereof; ring “A” is a five or six-membered optionally aromatic ring, z1 is —C—, —N—, —NL1-, or —CL1-; and z2-z6 are independently selected from —N—, —NH—, —NR*—, —O—, —S—, —CH—, —CR—, —CR*—, and in the case where ring “A” is a five membered ring, z4 is a bond (i.e., it is absent); where L1 is group —Xa—(CH2)r—(CH═CH)s—Xb—(CH2)y—(CH═CH)z—Xc—, where Xa, Xb, and Xc are independently a bond (i.e., absent), —O—, —S—, —NH—, —NR*— and “r,” “s,” “y,” and “z” are independently at each occurrence integers from 0-2; Z is selected from R*, OH, OR*, or NRNRN, wherein RN and R* are as defined above; and n and m are independently integers from 0-6; and topically acceptable salts thereof. |
