MEDICAL FLUID, A METHOD OF TREATMENT AND USE OF THE FLUID

摘要

A medical fluid for a harvested organ, tissue or part thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; noradrenaline; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenaline; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.

主权项

1. A method for preservation and/or evaluation of a harvested organ comprising:
circulating a medical fluid in the vascular system of the harvested organ, wherein: the medical fluid comprises: cocaine or a cocaine analogue; adrenaline; and noradrenaline; the harvested organ is at least partly denervated; and the medical fluid is effective in restoring vasotonus, reducing edema, and improving function of the harvested organ after transplantation thereof.