| 发明名称 |
KNOCK-IN RODENT COMPRISING A MUTATION IN AN ENDOGENOUS CRBN LOCUS AND METHODS OF USE THEREOF |
| 摘要 |
The present invention features a knock-in mouse comprising a mutation in an endogenous CRBN locus and methods of use thereof. |
| 申请公布号 |
US2016338326(A1) |
申请公布日期 |
2016.11.24 |
| 申请号 |
US201615074920 |
申请日期 |
2016.03.18 |
| 申请人 |
THE BROAD INSTITUTE, INC. ;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
EBERT BENJAMIN LEVINE;KRÖNKE JAN;CARR STEVEN A.;UDESHI NAMRATA D.;FINK EMMA |
| 分类号 |
A01K67/027;C12Q1/68;G01N33/50 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A knock-in mouse comprising a polynucleotide encoding a mutant murine CRBN polypeptide or a human CRBN polypeptide. |
| 地址 |
Cambridge MA US |
