METHODS FOR SCREENING TO IDENTIFY THERAPEUTIC AGENTS FOR ALZHEIMER'S DISEASE AND USE THEREOF

摘要

Methods for treating Alzheimer's Disease (AD) using modulators of lysosomal activity are described herein. More particularly, methods described herein relate to the use and application of compounds or agents that enhance lysosomal activity for the treatment of AD. In a particular aspect, the method relates to the use and application of compounds or agents that increase the pH of the lysosome and/or increase the overall activity of lysosomal proteases for the treatment of AD. Also described herein are methods and assays for screening to identify compounds or agents that increase the pH of the lysosome and/or increase the overall activity of lysosomal proteases for the treatment of AD.

主权项

1. A method for treating a subject with Alzheimer's Disease (AD), wherein the subject has impaired lysosomal activity, the method comprising administering to the subject an agent that enhances lysosomal activity.