发明名称 |
CROSS-LINKED POLYMERS AND MEDICAL PRODUCTS DERIVED FROM NUCLEOPHILICALLY ACTIVATED POLYOXAZOLINE |
摘要 |
One aspect of the invention relates to a biocompatible medical product comprising at least 1% by weight of dry matter of a covalently cross-linked polymer that is obtained by reacting a nucleophilically activated polyoxazoline (NU-PDX) with an electrophilic cross-linking agent other than an electrophilically activated polyoxazoline, said NU-PDX comprising m nucleophilic groups; and said electrophilic cross-linking agent comprising n electrophilic groups, wherein the m nucleophilic groups are capable of reaction with the n electrophilic groups to form covalent bonds; wherein m≧2, n≧2 and m+n≧5; and wherein the NU-PDX comprises at least 30 oxazoline units in case the electrophilic cross-linking agent is an isocyanate.;Also provided is a kit for producing the aforementioned biocompatible cross-linked polymer.;The biocompatible cross-linked polymers according to the invention have excellent implant and/or sealing characteristics. |
申请公布号 |
US2016319075(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
US201615210606 |
申请日期 |
2016.07.14 |
申请人 |
Bender Analytical Holding B.V. |
发明人 |
BENDER Johannes Caspar Mathias Elizabeth;HOOGENBOOM Richard;VAN HEST Jan Cornelis Maria;VAN GOOR Harry |
分类号 |
C08G69/48;A61L26/00 |
主分类号 |
C08G69/48 |
代理机构 |
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代理人 |
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主权项 |
1. A biocompatible tissue-adhesive medical product comprising at least 1% by weight of dry matter of a covalently cross-linked polymer that is obtained by reacting a nucleophilically activated polyoxazoline (NU-PDX) with an electrophilic cross-linking agent other than an electrophilically activated polyoxazoline, said NU-PDX comprising m nucleophilic groups; and said electrophilic cross-linking agent comprising n electrophilic groups, wherein the m nucleophilic groups are capable of reaction with the n electrophilic groups to form covalent bonds; wherein m≧2, n≧2 and m+n≧5; and wherein the NU-PDX comprises at least 30 oxazoline units in case the electrophilic cross-linking agent is an isocyanate, and wherein the tissue-adhesive properties derive from a reaction of non-reacted electrophilic groups in the cross-linked polymer with nucleophilic groups present in the tissue. |
地址 |
Overasselt NL |