TUMOR SPECIFIC ANTIBODIES AND USES THEREFOR

摘要

Provided are isolated antibodies, and fragments and derivatives thereof, which bind to tumor antigens. Also provided are compositions and delivery agents that include the disclosed antibodies and fragments and derivatives thereof; cells that produce the same; methods for producing the same; methods of using the same for detecting, targeting, and/or treating tumors and/or metastatic cells derived therefrom and/or tumor stem cells; and methods for predicting the recurrence of cancer in a subject.

主权项

1. An isolated antibody, or a fragment or derivative thereof, that binds to a tumor-associated mucin-1 (MUC1) epitope comprising SEQ ID NO: 4, wherein the tumor-associated epitope comprising SEQ ID NO: 4 is present in human pancreas tumor tissue or human breast tumor tissue, and further wherein the isolated antibody, fragment, or derivative does not appreciably bind to MUC1 present in normal human pancreas or breast tissue.