| 主权项 |
1. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein W is p is an integer of from 0 to 3; R1 is H or C1-C6 alkyl; ring A is phenyl or 5- or 6-membered heteroaryl; when ring A is phenyl, said phenyl is not substituted in ortho position; each R2 is independently selected from C1-C6 alkyl, R5O—, R6R7NC(O)—, R9C(O)N(R8)—, R10OC(O)—, R11C(O)O—, and halogen;
R5, R6, R7 and R8 are independently selected from H and C1-C6 alkyl;R9, R10 and R11 are independently selected from C1-6 alkyl;any alkyl is optionally substituted by one or more F; or two R2 attached to adjacent carbon atoms together form a methylenedioxy or ethylenedioxy biradical; R3 is C1-C6 alkyl; m is an integer of from 0 to 2; each R4 is independently selected from C1-C6 alkyl, R12O, halogen, R13R14NC(O)—, R16C(O)N(R15)—, R17OC(O)—, R18C(O)O—, R19S(O)2—, R20S(O)2N(H)—, NH2S(O)2—, R21C(O)—, N(R22)(R23)—, and —O—;
R12, R13, R14, R15, R22, and R23 are independently selected from H and C1-C6 alkyl;R16, R17, R18, R19, R20, and R21 are independently selected from C1-6 alkyl;any alkyl is optionally substituted by one or more F; or two R4 attached to adjacent atoms of ring B form, together with the atoms to which they are attached, a 5- or 6-membered heterocyclic or carbocyclic ring, or a benzene ring; ring B is 5- or 6-membered saturated or unsaturated carbocyclyl, 5- or 6-membered heteroaryl or phenyl; and optionally a pharmaceutically acceptable excipient, provided that the compound is not: 3-(4-chlorophenyl)-N-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine, N-(cyclohexylmethyl)-2,5-dimethyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-amine, 2,5-dimethyl-N-phenyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-amine, N-benzyl-2,5-dimethyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-amine, or 2,5-dimethyl-N-phenethyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-amine. |
