发明名称 TRIAZOLES AS KV3 INHIBITORS
摘要 Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.;
申请公布号 US2016318882(A1) 申请公布日期 2016.11.03
申请号 US201615208329 申请日期 2016.07.12
申请人 AUTIFONY THERAPEUTICS LIMITED 发明人 MARASCO Agostino;ALVARO Giuseppe;DÈCOR Anne;HAMPRECHT Dieter;DAMBRUOSO Paolo;TOMMASI Simona
分类号 C07D249/12;C07D401/04;C07D405/14;C07C255/48;C07C43/225 主分类号 C07D249/12
代理机构 代理人
主权项 1. A compound of formula (I): wherein: W is group (Wa), group (Wb) or group (Wc): wherein: R1 is H, C1-4alkyl, halo, haloC1-4alkyl, CN, C1-4alkoxy, or haloC1-4alkoxy; R2 is H, C1-4alkyl, C3-5 spiro carbocyclyl, haloC1-4alkyl or halo; R3 is H, C1-4alkyl, haloC1-4alkyl, halo; or R3 is absent; R13 is H, C1-4alkyl, haloC1-4alkyl, halo; or R13 is absent; R14 is H, C1-4alkyl, haloC1-4alkyl, halo; or R14 is absent; A is a 5 or 6 membered saturated or unsaturated heterocycle, with at least one O atom; which heterocycle is optionally fused with a cyclopropyl group, or a cyclobutyl group, or a cyclopentyl group to form a tricycle when considered together with the phenyl; X is CH or N; Y is CR15 or N; R15 is H or C1-4alkyl; R22 is H, Cl, F, C1-4alkyl; R23 is H, C1-4alkyl, Cl, CF3, O—C1-4alkyl, OCF3 or N(CH3)2; R24 is H, Cl, F, C1-4alkyl, O—C1-4alkyl, CN, OCF3 or CF3; R25 is H, Cl, F, O—C1-4alkyl or C1-4alkyl; and R26 is H or C1-4alkyl; wherein for R22 to R26, C1-4alkyl may be substituted by O-methyl; with the provisos that: not all of R22 to R26 may be H; when R4 is H, then R23 is methyl or CF3 and R22, R24, R25 and R26 are all H; when one of R22, R24, R25 or R26 is F, then at least one of R22 to R26 cannot be H or F; and when R24 is not H, at least one of R22 or R23 is not H R4 is H or C1-4 alkyl; wherein R2 and R3 may be attached to the same or a different ring atom; R2 may be attached to a fused ring atom; and wherein R13 and R14 may be attached to the same or a different ring atom; or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof.
地址 London GB