主权项 |
1. A compound of formula (I): wherein: W is group (Wa), group (Wb) or group (Wc): wherein: R1 is H, C1-4alkyl, halo, haloC1-4alkyl, CN, C1-4alkoxy, or haloC1-4alkoxy; R2 is H, C1-4alkyl, C3-5 spiro carbocyclyl, haloC1-4alkyl or halo; R3 is H, C1-4alkyl, haloC1-4alkyl, halo; or R3 is absent; R13 is H, C1-4alkyl, haloC1-4alkyl, halo; or R13 is absent; R14 is H, C1-4alkyl, haloC1-4alkyl, halo; or R14 is absent; A is a 5 or 6 membered saturated or unsaturated heterocycle, with at least one O atom; which heterocycle is optionally fused with a cyclopropyl group, or a cyclobutyl group, or a cyclopentyl group to form a tricycle when considered together with the phenyl; X is CH or N; Y is CR15 or N; R15 is H or C1-4alkyl; R22 is H, Cl, F, C1-4alkyl; R23 is H, C1-4alkyl, Cl, CF3, O—C1-4alkyl, OCF3 or N(CH3)2; R24 is H, Cl, F, C1-4alkyl, O—C1-4alkyl, CN, OCF3 or CF3; R25 is H, Cl, F, O—C1-4alkyl or C1-4alkyl; and R26 is H or C1-4alkyl; wherein for R22 to R26, C1-4alkyl may be substituted by O-methyl; with the provisos that: not all of R22 to R26 may be H; when R4 is H, then R23 is methyl or CF3 and R22, R24, R25 and R26 are all H; when one of R22, R24, R25 or R26 is F, then at least one of R22 to R26 cannot be H or F; and when R24 is not H, at least one of R22 or R23 is not H R4 is H or C1-4 alkyl; wherein R2 and R3 may be attached to the same or a different ring atom; R2 may be attached to a fused ring atom; and wherein R13 and R14 may be attached to the same or a different ring atom; or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof. |