A method for the preparation of a nicotine-containing particulate material with a crystalline cellulose (in particular MCC)

摘要

A method for preparation of a nicotine-containing particulate material for release of nicotine, the method comprising dissolving nicotine or a pharmaceutically acceptable salt, complex or solvate thereof in a hydrophilic solvent and entrapping the nicotine contained in hydrophilic solvent in a crystalline cellulose preferably microcrystalline cellulose, to obtain a particulate material. The particulate material is stable upon storage and releases nicotine relatively fast.