发明名称 |
STABLE AND FILTERABLE ENVELOPED VIRUS FORMULATIONS |
摘要 |
Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. −20° C.). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10. |
申请公布号 |
EP1807511(A2) |
申请公布日期 |
2007.07.18 |
申请号 |
EP20050817250 |
申请日期 |
2005.11.04 |
申请人 |
WELLSTAT BIOLOGICS CORPORATION |
发明人 |
CHEN, TZER-FEN;JANG, JOUHN-WERN;MILLER, JEFFREY, A. |
分类号 |
A61K47/26;A61K9/00;C12N7/00 |
主分类号 |
A61K47/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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