PREVENTION OR REVERSAL OF APOE4 INDUCED BRAIN PATHOLOGY BY ACTIVATION OF VEGF RECEPTORS

摘要

The invention relates to prevention, treatment and slowing the progression of brain pathology in a disease or condition associated with ApoE4 genotype such as Alzheimer's Disease (AD) in a subject having the ApoE4 genotype through activation of Vascular Endothelial Growth Factor Receptor (VEGF) in the hippocampus or a sub-region thereof.