This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.
申请公布号
WO2016142660(A1)
申请公布日期
2016.09.15
申请号
WO2016GB50577
申请日期
2016.03.04
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
发明人
GOW, Neil, Andrew, Robert;RUDKIN, Fiona, Marion;ERWIG, Lars-Peter;JENSEN, Allan