| 摘要 |
Modified capsular saccharides comprising a blocking group at a hydroxyl g roup position on at least one of the monosaccharide units of the correspondi ng native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -OX-Y (Ia) or -0-R1 (Ib) wherein X is C(O), S(O) or SO2; Y is NR1R2 or R3; R1 is C1-6 alkyl substituted with 1, 2 or 3 groups independentl y selected from hydroxyl, sulphydryl and amine; R2 is H or C1-6 alkyl; and R 3 is C1-6 alkyl; processes for modifying a capsular saccharide with the bloc king groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmace utical compositions comprising the modified capsular saccharides and/or sacc haride-protein conjugates; and methods and uses of the same.
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