Methods For Identifying Complex Disease Subtypes

摘要

The present technology relates to methods that determine one or more subgroups of subjects within a population of subjects diagnosed with the same disease. In some embodiments, the methods include determining differential gene expression of at least one subgroup in the population using divisive Shuffling Approach (VIStA). In some embodiments, the method includes determining at least one clinical characteristic of each subgroup and/or determining a significant set of clinical characteristics of the disease order.

主权项

1. A method for determining at least one subgroup of subjects from a population of subjects diagnosed with the same disease comprising:
(A) obtaining the population of subjects diagnosed with the same disease; (B) dividing the population of subjects into a first group and a second group; (C) calculating the number of differentially expressed genes between the first group and the second group; (D) exchanging one subject from the first group with one subject from the second group; (E) re-calculating the number of differentially expressed genes between the first group and the second group, wherein the exchange of subjects between the first group and second group is maintained if the number of differentially expressed genes between the first group and the second group increases, and wherein the exchange of subjects is rejected if the number of differentially expressed genes between the first group and the second group remains the same or decreases; and (F) repeating steps D-E.