COMPOSITION, KIT AND METHOD FOR INHIBITION OF IL-21 MEDIATED ACTIVATION OF HUMAN CELLS

摘要

The present invention relates to a synergistic composition, kit and method for inhibition and/or neutralization of IL-21 mediated activation of human cells comprising (i) a first agent being an antibody or antibody fragment thereof directed to a first epitope of IL-21, and (ii) a second agent being an antibody or antibody fragment thereof directed to a second epitope of IL-21. The inhibition and/or neutralization of IL-21 mediated activation of human cells is for use in the prophylaxis and/or treatment of disease of immune-related conditions including inflammatory disease, autoimmunity and lymphomas.