| 发明名称 |
OCULAR FORMULATIONS FOR DRUG-DELIVERY AND PROTECTION OF THE ANTERIOR SEGMENT OF THE EYE |
| 摘要 |
The present application relates to topical formulations comprising Compound-I;;or its free base, and a second active agent selected from nicotinic acid, nicotinamide, and vitamin K, and a combination thereof, for treating ocular neovascularization. The present application also relates to pharmaceutical compositions comprising particles of Compound-I or its free base, and suspension formulations comprising the particle compositions of Compound-I or its free base. |
| 申请公布号 |
US2016206599(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201615080893 |
申请日期 |
2016.03.25 |
| 申请人 |
PanOptica, Inc. |
发明人 |
Bingaman David P.;Chaney Paul G.;Wax Martin B. |
| 分类号 |
A61K31/425;A61K9/08;A61K31/122;A61K9/00 |
主分类号 |
A61K31/425 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An aqueous, topical, ocular, suspension formulation, comprising:
a. about 0.1% to about 2.0% (w/v) a compound of Formula II: or a pharmaceutically acceptable salt thereof; b. about 0.00001% to about 0.0001% (w/v) vitamin K3, or a pharmaceutically acceptable salt thereof; c. about 0.6% (w/v) tromethamine; d. about 2.0% (w/v) glycerin; e. about 0.2% (w/v) hydroxyethyl cellulose; and f. about 0.08% (w/v) hypromellose. |
| 地址 |
Bernardsville NJ US |
