发明名称 |
METHOD FOR TREATING OBESITY, DIABETES, CARDIOVASCULAR AND KIDNEY DISEASES BY REGULATING GPR30/GPER ACTIVITY |
摘要 |
The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS). |
申请公布号 |
WO2016144647(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
WO2016US20452 |
申请日期 |
2016.03.02 |
申请人 |
STC.UNM |
发明人 |
PROSSNITZ, Eric, R.;SHARMA, Geetanjali;BARTON, Matthias;MEYER, Matthias, R. |
分类号 |
A61K31/435;A61P3/10;A61P9/00;A61P13/12;A61P25/28 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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