ABUSE-RESISTANT DRUG FORMULATIONS

摘要

Disclosed are abuse resistant oral pharmaceutical compositions that reduce the likelihood of improper administration of drugs that are susceptible to abuse. The oral pharmaceutical formulations contain abuse deterrent agents that cause discomfort to the user when administered in an improper manner and make the extraction of an active ingredient more difficult. Methods of making and using the compositions are also disclosed.

主权项

1. An abuse-resistant, immediate-release liquid pharmaceutical composition, comprising a mixture of an effective amount at least one pharmaceutically active agent susceptible to abuse, an organic vehicle, a surfactant, a co-solvent, and optionally a viscosity-building polymer; wherein said organic vehicle, surfactant, and co-solvent co-elute with the pharmaceutically active agent when exposed to a solvent, and wherein the viscosity-building polymer is present in an amount that slows the release of the pharmaceutically active agent if multiple unit doses of the composition are administered.