发明名称 |
PROCESS FOR THE SYNTHESIS OF THE ACE INHIBITOR TRANDOLAPRIL |
摘要 |
<p>A process for the synthesis of trandolapril which comprises condensing N—[I—(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride with trans octahydro-1H-indole-2-carboxylic acid in a first organic solvent comprising a water immiscible inert organic solvent and in the presence of a base, and isolating trandolapril from a second organic solvent. N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride may also be condensed with (2S,3aR,7aS) octahydro-1H-indole-2-carboxylic acid in a first organic solvent and in the presence of a base, and trandolapril isolated. There is also provided a process for the resolution of racemic trans octahydro-1H-indole-2-carboxylc acid.</p> |
申请公布号 |
EP1899300(A2) |
申请公布日期 |
2008.03.19 |
申请号 |
EP20060755717 |
申请日期 |
2006.07.05 |
申请人 |
CIPLA LIMITED |
发明人 |
KANKAN, RAJENDRA NARAYANRAO;RAO, DHARMARAJ RAMACHANDRA;PHULL, MANJINDER SINGH;SAWANT, ASHWINI;BIRARI, DILIP RAMDAS |
分类号 |
C07D209/42 |
主分类号 |
C07D209/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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