POLYMER TAGGED NUCLEOTIDES FOR SINGLE MOLECULE ELECTRONIC SNP ASSAY

摘要

This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer- conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.