发明名称 |
GENE THERAPY OF CHRONIC GRANULOMATOUS DISEASE |
摘要 |
<p>The present invention relates to the field of gene therapy. In particular, it provides a nucleic acid encoding gp91phox, wherein codon-usage of said gp91phox nucleic acid is optimized for expression in human cells, and an expression construct, in particular a retroviral vector suitable for gene therapy of chronic granulomatous disease, comprising said nucleic acid. Additionally, methods of preparing cells comprising the construct, said cells and pharmaceutical compositions comprising the construct or cells of the invention are provided.</p> |
申请公布号 |
WO2009012959(A1) |
申请公布日期 |
2009.01.29 |
申请号 |
WO2008EP05956 |
申请日期 |
2008.07.21 |
申请人 |
VISION 7 GMBH;CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS;STEIN, STEFAN;GREZ, MANUEL;SCHAMBACH, AXEL |
发明人 |
STEIN, STEFAN;GREZ, MANUEL;SCHAMBACH, AXEL |
分类号 |
C12N9/02;A61K48/00 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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