发明名称 |
NOVEL ANTI-TRANSFERRIN RECEPTOR ANTIBODY THAT PASSES THROUGH BLOOD-BRAIN BARRIER |
摘要 |
Disclosed are novel anti transferrin receptor antibody that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. The fusion protein comprises amino acid sequences of an anti-human transferrin receptor antibody that recognizes an amino acid sequence selected from the group consisting of SEQ ID NOs:1, 2, and 3, and of other protein that is bound thereto on the C- terminal side. |
申请公布号 |
EP3088518(A1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20140873852 |
申请日期 |
2014.12.24 |
申请人 |
JCR PHARMACEUTICALS CO., LTD. |
发明人 |
SONODA, HIROYUKI;MORIMOTO, HIDETO;KOSHIMURA, YURI;KINOSHITA, MASAFUMI;TAKAGI, HARUNA;YOSHII, YOSHIKO |
分类号 |
C12N15/09;C07K16/18;C07K19/00;C12N5/071 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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