发明名称 |
CATIONIC OIL-IN-WATER EMULSIONS |
摘要 |
PROBLEM TO BE SOLVED: To provide cationic oil-in-water-type emulsions.SOLUTION: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule, thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.SELECTED DRAWING: None |
申请公布号 |
JP2016204389(A) |
申请公布日期 |
2016.12.08 |
申请号 |
JP20160172965 |
申请日期 |
2016.09.05 |
申请人 |
NOVARTIS AG |
发明人 |
LUIS BRITO;ANDREW GEALL;DEREK O'HAGAN;SINGH MANMOHAN |
分类号 |
A61K9/107;A61K31/7105;A61K39/00;A61K47/02;A61K47/06;A61K47/10;A61K47/12;A61K47/14;A61K47/18;A61K47/24;A61K47/26;A61K47/28;A61K47/34;A61K47/44;A61K47/48;A61K48/00;A61P31/00;A61P37/04 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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