CEPHEM DERIVATIVE USING INDIUM AND ZINC AND PREPARATION METHOD THEREOF

摘要

PURPOSE: A cephem derivative using indium and zinc and a preparation method thereof are provided. The cephem derivative is used as an intermediate in manufacturing beta-lactamase inhibiting agent and antibiotics CONSTITUTION: Cephem derivative as represented by formula(I) is prepared by reacting 7-oxo cephalosporin derivative as represented by formula(I'), allyl halide as represented by formula(II), acetylene halide as represented by formula(III), solvent in the presence of indium or zinc. In the formula (I): R1 is allyl derivative or acetylene derivative; R2 is hydrogen, carboxylic acid salt(sodium salt and potassium salt as inorganic salt, alkyl amine salt, aromatic amine salt as organic salt) or carboxy protecting group(4-methoxybenzyl, diphenylmethyl, 4-nitrobenzyl and useful thing as protecting group of molecule in penicillin or cephalosporin compound field); R3 is hydrogen, halogen, hydroxy or acetoxy group; and R4,R5,R6 are each hydrogen, methyl, ethyl, carboxylic acid or ester.