| 摘要 |
FIELD: medicine. ^ SUBSTANCE: there is described binding molecule which expresses ability to be bound with human polypeptide Nogo-A, or human NiG, or human NiG-D20, or human Nogo-A-342-357 epitope NQQELPTALTKLVKED, where the specified binding molecule is chosen from the group including V-cell or hybridoma produced antibodies, chimeric or humanised antibodies F(ab')2 or Fab antibody fragments, one-chained antibodies or single-domain antibodies. There is offered polynucleotide coding said molecule. There is also offered expression vector containing said polynucleotide. There is presented pharmaceutical composition for therapy that ensures nerve reparation, containing said binding molecule in therapeutically effective amount in a combination at least with one pharmaceutically acceptable carrier or a diluent. There is described epitope Nogo-A of human protein, including amino acid sequence ELPTALTKLV or NQQELPTALTKLVKED. ^ EFFECT: invention can be used in nerve reparation. ^ 14 cl, 2 tbl, 8 ex |
