ANTI FGF23 ANTIBODY AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).

主权项

1. A method for treating a disease having excessive activity of FGF23, comprising administering an antibody or functional fragment thereof to a subject, wherein the antibody or functional fragment thereof binds to FGF23 and comprises:
(a) a heavy chain comprising at least CDR1 shown by SEQ ID NO: 40, CDR2 shown by SEQ ID NO: 41, or CDR3 shown by SEQ ID NO: 42; or (b) a light chain comprising at least CDR1 shown by SEQ ID NO: 43, CDR2 shown by SEQ ID NO: 44, or CDR3 shown by SEQ ID NO: 45.