| 发明名称 |
IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING COTH |
| 摘要 |
The invention provided Mucorales CotH antibodies, polypeptides, encoding nucleic acid molecules, and uses thereof. The Mucorales CotH antibodies, polypeptides and encoding nucleic acids disclosed herein can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis. |
| 申请公布号 |
US2016159887(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201615043025 |
申请日期 |
2016.02.12 |
| 申请人 |
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER |
发明人 |
IBRAHIM Ashraf S.;LIU Mingfu;GHEBREMARIAM Teklegiorgis;FU Yue;EDWARDS John E.;FILLER Scott |
| 分类号 |
C07K16/14;G01N33/569 |
主分类号 |
C07K16/14 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated anti-Mucorales CotH antibody, or binding fragment thereof, that specifically binds to a polypeptide expressed on the cell surface of a fungus of the order Mucorales, wherein the polypeptide comprises an amino acid sequence having at least 65% sequence identity to SEQ ID NO: 39 or SEQ ID NO: 40. |
| 地址 |
TORRANCE CA US |
