Bone graft implants containing allograft

摘要

Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.

主权项

1. A porous, composite hone graft implant comprising:
a first component comprising a conformable, porous matrix including a plurality of randomly oriented, overlapping bioactive glass fibers, and bioactive glass particulates distributed throughout the fibers to increase compression resistance and provide structural support to the matrix; and a second component comprising an allograft material; the fibers of the first component being freely movable with respect to one another at at least some of their intersections; wherein at least some of the bioactive glass fibers and bioactive glass particulates together are at east partially encased in a bioactive glass shell to form an encased fibrous cluster; and further wherein the composite implant comprises a pore size distribution including pores characterized by pore diameters ranging from about 100 nanometer to about 1 millimeter.