Sceletium extract and uses thereof

摘要

A composition including as an active ingredient an extract of a plant of the family Mesembryanthemaceae with mesembrenol and mesembrenone as the two major alkaloids present. The invention also relates to the use of the composition as a PDE4 inhibitor and as a serotonin-uptake inhibitor, preferably applied in formulations for the use of the composition as a dual serotonin-uptake inhibitor and PDE4 inhibitor. The invention extends to compositions, such as pharmaceutical compositions or compositions used as dietary supplements, the total alkaloid content of which includes at least 80% (w/w) combined content of mesembrenol and mesembrenone, less than 5% (w/w) mesembrine, and at least 7% (w/w) mesembranol.

主权项

1. A composition, in unit dosage form, for reducing one or more conditions selected from the group consisting of anxiety, stress, tension, sleep disturbance, and depression in a patient in need thereof, said composition comprising an effective amount of a Sceletium tortuosum extract, wherein the extract contains the alkaloids mesembrenol and mesembrenone, wherein combined content of mesembrenol and mesembrenone is greater than 80% (w/w) of the total alkaloid content in the extract, wherein the content of the alkaloid mesembrine is less than 15% (w/w) of the total alkaloid content in the extract, and wherein the unit dosage form is selected from the group consisting of an aqueous-ethanolic tincture, a tablet, an enteric coated tablet, a capsule, a dissolvable wafer, a lotion, a cream, an ointment, and a skin patch.