| 摘要 |
The present invention generally relates to cell growth modulators, methods of screening for such modulators and methods of using such modulators. In particular, the present invention provides a method of identifying a modulator of cell growth, which method comprises: a) assessing activity of a site-specific DNA recombinase or a type I DNA topoisomerase in the presence of a test substance; b) assessing activity of said site-specific DNA recombinase or said type I DNA topoisomerase in the absence of said test substance; and c) comparing said activities assessed in steps a) and b), whereby a difference in said activity assessed in step a) and said activity assessed in step b) indicates that said test substance modulates cell growth. Peptide cell growth inhibitors and methods of using such inhibitors in treating certain diseases or disorders, e.g., tumor, cancer and bacterial infection, are also provided. |
