METHOD FOR OBTAINING APRIL-BINDING PEPTIDES, PROCESS FOR PRODUCING THE PEPTIDES, APRIL-BINDING PEPTIDES OBTAINABLE WITH SAID METHOD/PROCESS AND USE OF THE APRIL-BINDING PEPTIDES

摘要

The invention relates to a method for obtaining APRIL-binding peptides. With this method APRIL-binding peptides may be obtained and/or selected. Further aspects of the invention relate to a cell comprising a nucleotide sequence coding for an APRIL-binding peptide according to the invention, a process for producing an APRIL-binding peptide and the APRIL-binding peptide obtainable in the production process and/or the selection method. In view of the possible utility of the APRIL-binding peptides according to the invention, further aspects of the invention relate to diagnostic uses of an APRIL binding peptide of the invention.

主权项

1. Method for obtaining APRIL-binding peptides comprising:
providing a library of binder peptides; selecting APRIL-binding peptides from the library by means of affinity selection using a target peptide immobilized on a solid support, said target peptide comprising a number of APRIL epitopes and an APRIL receptor-binding region of APRIL; characterized in that, the target peptide is in interaction with a peptide, the shielding peptide, comprising an APRIL-binding region of an APRIL receptor or of an APRIL-binding equivalent thereof.