| 发明名称 |
LEUKEMIA STEM CELL TARGETING LIGANDS AND METHODS OF USE |
| 摘要 |
The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (LSCs) and targeted therapy against leukemia mediated at least in part by CLL1-expressing LSCs. |
| 申请公布号 |
US2016237118(A1) |
申请公布日期 |
2016.08.18 |
| 申请号 |
US201615142912 |
申请日期 |
2016.04.29 |
| 申请人 |
The Regents of the University of California |
发明人 |
PAN Chong-xian;ZHANG Hongyong |
| 分类号 |
C07K7/06;G01N33/574;A61K51/08 |
主分类号 |
C07K7/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A peptide comprising the amino acid sequence motif LR(S/T), wherein the peptide is no longer than 10 amino acids in length and binds to C-type lectin-like molecule-1 (CLL1). |
| 地址 |
Oakland CA US |
