| 发明名称 |
PROCESS FOR PREPARATION OF DIMETHYL FUMARATE |
| 摘要 |
The present invention relates to a process for the preparation of dimethyl fumarate, a compound of formula I, in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate. |
| 申请公布号 |
US2016237021(A1) |
申请公布日期 |
2016.08.18 |
| 申请号 |
US201415025056 |
申请日期 |
2014.09.22 |
| 申请人 |
GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED |
发明人 |
BHIRUD Shekhar Bhaskar;BHUSHAN Kumar Hari;SWAMY H M Veerabhadra;PATIL Dilipkumar Jibhau;DABE Avikumar Digambar |
| 分类号 |
C07C69/60;C07C67/60;C07C67/08 |
主分类号 |
C07C69/60 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the preparation of dimethyl fumarate, a compound of formula I,in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate, the process comprising:
(a) reacting fumaric acid with an acyl halide in methanol to obtain dimethyl fumarate, a compound of formula I; (b) subjecting dimethyl fumarate, the compound of formula I, to treatment with a base; and (c) isolating dimethyl fumarate, the compound of formula I, in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate. |
| 地址 |
Mumbai IN |
