| 摘要 |
In some embodiments, the present invention may be directed to various pharmaceutical dosage units comprising at least one opioid analgesic in combination with a benzodiazepine blocker. In some embodiments, the present invention may be directed to various methods of treatment using such pharmaceutical dosage units. In some embodiments, these pharmaceutical dosage units may be used for treating: pain, chronic pain, sub-acute pain, chronic and sub-acute pain, anxiety, addiction in general, opiate addiction, and benzodiazepine addiction, opiate and benzodiazepine addiction; opiate dependence, benzodiazepine dependence; and for reducing a likelihood of overdose associated with concomitant use of opiates with benzodiazepines, and for mitigating against drug diversion. These pharmaceutical dosage units may be delivered by a variety of delivery methods and/or delivery systems, comprising one or more of: mucosal, sublingual, buccal, nasal inhalation, depot, implantable rod, transdermal patch, parenteral, intravenous, intrathecal, subcutaneous, intramuscular, and the like. |
