METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT

摘要

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations.

主权项

1. A method of treating an individual suffering from AML, wherein the individual is greater than 55 years old, comprising administering araC to the individual based on a decision to treat the individual, wherein the decision to treat the individual is based at least in part on the results of a test comprising
(i) contacting cells from a sample from the individual with one or more agents that induce apoptosis; (ii) determining the level of apoptosis in the cells by a process that comprises determining, in single cells, the level of a marker of apoptosis.