| 摘要 |
PROBLEM TO BE SOLVED: To provide a composition such as a pharmaceutical, food and drink, etc., for fundamentally preventing, improving or treating heart disease, liver failure, etc., which are difficult to be treated conventionally by finding out a safe substance having highly efficient differentiation activity from stem cells to mesodermal cells, endodermal cells or mesendodermal cells.SOLUTION: A differentiation inducer from stem cells to mesodermal cells, endodermal cells or mesendodermal cells includes trans-4-hydroxy-L-proline. The mesendodermal cell differentiation inducer can efficiently induce the differentiation of the endodermal cells such as myocardium, etc., endodermal cells such as hepatocyte, etc., and mesendodermal cells from the stem cells, and can provide a composition such as a pharmaceutical, food and drink, etc., for fundamentally preventing, improving or treating heart disease, liver failure, etc., which are difficult to treat conventionally. |
