| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).SOLUTION: A method for assessing a human subject's risk for developing AMD comprises: (a) determining in a biological sample from a subject the presence or absence of risk alleles of common allelic variants associated with AMD at a plurality of independent loci; and (b) calculating the polygenic score for the subject, wherein a high polygenic score indicates a higher risk for developing advanced AMD.SELECTED DRAWING: None |
