Low dose no donor-containing transdermal patch

摘要

The present invention is drawn to a transdermal patch for the delivery of a nitroglycerin or other NO donor. The patch can comprise a backing layer, and a nitroglycerin-containing composition or other NO donor-containing composition which is supported at least in part by the backing layer. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 mug/hour to about 70 mug/hour. In one embodiment, the transdermal patch can provide a delivery rate at the drug delivery zone of from about 1 mug/cm²/day to about 600 mug/cm²/day. In another embodiment, the transdermal patch can contain from 6 wt % to 18 wt % of the nitric oxide donor, e.g., nitroglycerin. In each embodiment, the patch can contain at least 450 mug/cm² of nitroglycerin.