The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
申请公布号
EP1578393(A4)
申请公布日期
2008.03.19
申请号
EP20030715981
申请日期
2003.02.04
申请人
GENE LOGIC, INC.
发明人
MENDRICK, DONNA;PORTER, MARK;JOHNSON, KORY;HIGGS, BRANDON;CASTLE, ARTHUR;ORR, MICHAEL;ELASHOFF, MICHAEL