BENZIMIDAZOLE DERIVATIVE

摘要

Disclosed is a novel and excellent therapeutic and/or prophylactic method for prostatomegaly, prostate cancer or the like, which relies on the selective inhibitory activity on 17 .beta. HSD type 5. It is found that an indole or benzimidazole derivative having a phenyl group substituted on the nitrogen atom in an indole or benzimidazole ring wherein the phenyl group has a COOH substituted therein has a potent selective inhibitory activity on 17 .beta. HSD type 5, and that the indole or benzimidazole derivative can be used as a therapeutic and/or prophylactic agent for a disease associated with 17 .beta. HSD type 5 such as prostatomegaly, prostate cancer or the like without any adverse side effect induced by the decrease in the testosterone level.