Compositions for Oral Administration of Zoledronic Acid or Related Compounds for Treating Paget's Disease of Bone

摘要

Oral dosage forms of bisphosphonate compounds, such as zoledronic acid, can be used to treat or alleviate pain or related conditions. The oral bioavailabillty of zoledronic acid can be enhanced by administering the zoledronic acid in the disodium salt form

主权项

1. A method of treating Paget's disease of bone, comprising orally administering zoledronic acid in a disodium salt form to a mammal in need thereof, wherein the zoledronic acid in the disodium salt form is administered in an amount and frequency that results in an AUC of zoledronic acid, over a four week period, that is about 100 ng·h/mL to about 2000 ng·h/mL.