| 发明名称 |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIMINUTION OF BONE TISSUE |
| 摘要 |
A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV%) by 3 folds as compared to free Withaferin A (WFA). |
| 申请公布号 |
US2016158152(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201414904981 |
申请日期 |
2014.07.16 |
| 申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
TRIVEDI Ritu;MISHRA Prabhat Ranjan;SINGH Divya;KHEDGIKAR Vikram;KUSHWAHA Priyanka;ADHIKARY Sulekha;CHOUDHARY Dharmendra;GAUTAM Jyoti;KUMAR Avinash;KARVANDE Anirudha;VERMA Ashwni;SHARMA Shweta;TRIVEDI Prabodh K;SANGWAN Neelam S.;SANGWAN Rajender S. |
| 分类号 |
A61K9/127;A61K47/36;A61K47/26;A61K31/585 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition for prevention and treatment of diminution of bone comprising: a compound selected from the group consisting of Withaferin A (WFA), Withanolide A, and Withanone in a concentration in the range of 0.1 to 0.5% w/v, and pharmaceutically acceptable excipients selected from the group comprising lipids, and polymers. |
| 地址 |
Rafi Marg, New Delhi IN |
