| 摘要 |
The invention relates to derivatives of morphine-6-glucuronide having formula (I) wherein R1 is a 5-membered heteroaromatic group optionally substituted by one or more substituents selected from among halogen atoms and (C-C) alkyl, halogen, hydroxyl, halo(C-C) alkyl, halo(C-C) alkyloxy, (C-C) alkyloxy, aryl(C-C) alkyl and aryl groups, said aryl group being optionally substituted by one or more groups selected from among (C-C) alkyl, halo(C-C) alkyl, hydroxyl and (C-C) alkyloxy groups, in the form of a base or acid addition salt, as well as in hydrate or solvate form. The invention also relates to the preparation method thereof and to the use of same in therapeutics. |
