METHODS FOR CHARACTERIZING TIME-BASED HEPATOTOXICITY

摘要

Methods of characterizing the time-based hepatotoxicity of a test compound are provided. In some embodiments the provided methods allow prediction of the hepatotoxic potential of a test compound in a way that is improved relative to that acheivable with prior art methods. In some embodiments the methods may be used to quantify the relationship between measurements or estimates of toxicity made at different, successive points in time, to provide highly meaningful tool to assess the likely in vivo hepatotoxicity of test compounds in vivo.