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1. A compound of Formula (I):or a pharmaceutically acceptable salt thereofwherein
A is CR1E or a nitrogen atom, X—Y—Z is N—CO—NR3AR3B, N—CO—R4, CR2E—CO—NR3AR3B, CR2E—NR5—COR4 or CR2E—NR5—CONR3AR3B, R1A is a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, a C3-6 cycloalkyl, —NR6R7, —CONR6R7 and —NR6COR7; a C3-10 cycloalkyl or a 4- to 10-membered saturated heterocycle (wherein the cycloalkyl and the saturated heterocycle may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR6R7); a C1-6 alkoxy optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, —NR6R7, —CONR6R7 and —NR6COR7; a hydrogen atom; a halogen; —NR6R7; a cyano group; —CONR6R7; —NR6COR7; or —SO2R6, provided that both R6 and R7 are not a hydrogen atom, R1B to R1E are each independently a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, a C3-6 cycloalkyl, —NR6′R7′, —CONR6′R7′ and —NR6′COR7′; a C3-10 cycloalkyl or a 4- to 10-membered saturated heterocycle (wherein the cycloalkyl and the saturated heterocycle may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy, —NR6′R7′, —CONR6′R7′ and —NR6′COR7′); a C1-6 alkoxy or a C3-10 cycloalkoxy (wherein the alkoxy and the cycloalkoxy may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, —CONR6′R7′ and —NR6′COR7′); a hydrogen atom; a hydroxy group; a halogen; an aryl or a heteroaryl (wherein the aryl and the heteroaryl may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a halogen, a hydroxy group, a C1-6 alkyl optionally substituted with 1 to 5 fluorine atoms, a C1-6 alkoxy, —NR6′R7′, —CONR6′R7′ and —NR6′COR7′); —NR6′R7′; a cyano group; —CONR6′R7′; —NR6′COR7′; or —SO2R6′, provided that both R6′ and R7′ are not a hydrogen atom, R2A to R2E are each independently a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a halogen, a hydroxy group, a C1-6 alkoxy and —NR8R9; a hydrogen atom; a halogen; a hydroxy group; or a C1-6 alkoxy optionally substituted with 1 to 5 fluorine atoms, or when two of R2A to R2E are a C1-6 alkyl, they may be taken together to form a 4- to 10-membered saturated carbocyclic ring (which may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR8R9), R3A, R3B and R4 are each independently a C1-10 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of phenyl, a monocyclic heteroaryl, a 4- to 10-membered saturated heterocycle, a C3-10 cycloalkyl, a fluorine atom, a hydroxy group, a C1-6 alkoxy optionally substituted with 1 to 5 fluorine atoms, and —NR10R11; a C3-10 cycloalkyl; a 4- to 10-membered saturated heterocycle; phenyl; a monocyclic heteroaryl; or a hydrogen atom, wherein the cycloalkyl, the saturated heterocycle, the phenyl and the monocyclic heteroaryl may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of an aryl (which may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a C1-6 alkoxy and —NR10R11), a halogen, a hydroxy group, a C1-6 alkyl (which may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a C1-6 alkoxy and —NR10R11), a C1-6 alkoxy (which may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a C3-6 cycloalkyl, a C3-6 cycloalkyl-C1-6 alkyl, a C1-6 alkoxy and a fluorine atom), a C1-6 alkylcarbonyl and —NR10R11, provided that (1) R3A and R3B may be taken together to form a 4- to 10-membered saturated heterocycle (which may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR10R11), (2) only one of R3A and R3B can be a hydrogen atom, and (3) R4 is not a hydrogen atom, R5 to R11, R6′ and R7′ are the same or different (each symbol is also the same or different when each symbol exists plurally) and are a hydrogen atom or a C1-6 alkyl optionally substituted with 1 to 5 fluorine atoms, provided that in each combination of R6-R7, R6′-R7′, R8-R9, and R10-R11, (1) when one is a hydrogen atom, the other one is not a hydrogen atom, and (2) each combination may be taken together to form a 4- to 10-membered saturated heterocycle (which may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR6R7), and n is 1 or 2. |
