发明名称 |
POLYMERIC CONJUGATES OF PACLITAXEL AND DOCETAXEL WITH PH-CONTROLLED RELEASING OF THE CANCEROSTATIC AGENT |
摘要 |
The present invention describes a polymeric conjugate consisting of a derivative of a cytostatic agent selected from the group of taxanes, in particular paclitaxel (PTX), docetaxel (DTX) or larotaxel (LTX), and a polymeric carrier prepared on the basis of a linear or biodegradable grafted copolymer consisting of units of the basic copolymer N-(2-hydroxypropyl)methacroylamide (HPMA) and units containing methacryloylated hydrazones of amino acids or oligopeptides. The invention also deals with a method of preparation of the above mentioned polymeric conjugate, in which the polymeric carrier is subjected to polymer-analogous transformation of the carrier by reaction with an ester of the oxo acid and the cytostatic agent. The polymeric conjugate is used for the preparation of a medicament for treatment of tumour diseases. |
申请公布号 |
UA104187(C2) |
申请公布日期 |
2014.01.10 |
申请号 |
UA20110015172 |
申请日期 |
2010.02.09 |
申请人 |
ZENTIVA, K.S. |
发明人 |
ETRYCH, TOMAS;ULBRICH, KAREL;RIHOVA, BLANKA;SIROVA, MILADA |
分类号 |
A61K31/337;A61K47/48 |
主分类号 |
A61K31/337 |
代理机构 |
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